APOBEC3F (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pU

Length: 1122 Sequence: atgaagcctc acttcagaaa cacagtggag cgaatgtatc gagacacatt ctcctacaac ttttataata gacccatcct ttctcgtcgg aataccgtct ggctgtgcta cgaagtgaaa acaaagggtc cctcaaggcc ccgtttggac gcaaagatct ttcgaggcca ggtgtattcc cagcctgagc accacgcaga aatgtgcttc ctctcttggt tctgtggcaa ccagctgcct gcttacaagt gtttccagat cacctggttt gtatcctgga ccccctgccc ggactgtgtg gcgaagctgg ccgaattcct gtctgagcac cccaatgtca ccctgaccat ctccgccgcc cgcctctact actactggga aagagattac cgaagggcgc tctgcaggct gagtcaggca ggggcccgtg tgaagattat ggacgatgaa gaatttgcat actgctggga aaactttgtg tacagtgaag gtcagccatt catgccttgg tacaaattcg atgacaatta tgcattcctg caccgcacgc taaaggagat tctcagaaac ccgatggagg caatgtatcc acacatattc tacttccact ttaaaaacct acgcaaagcc tatggtcgga acgaaagctg gctgtgcttc accatggaag ttgtaaagca ccactcacct atctcctgga agaggggcgt cttccgaaac caggtggatc ctgagaccca ttgtcatgca gaaaggtgct tcctctcttg gttctgtgac gacatactgt ctcctaacac aaactacgag gtcacctggt acacatcttg gagcccttgc ccagagtgtg caggggaggt ggccgagttc ctggccaggc acagcaacgt gaatctcacc atcttcaccg cccgcctcta ctacttctgg gatacagatt accaggaggg gctccgcagc ctgagtcagg aaggggcctc cgtggagatc atgggctaca aagattttaa atattgttgg gaaaactttg tgtacaatga tgatgagcca ttcaagcctt ggaaaggact aaaatacaac tttctattcc tggacagcaa gctgcaggag attctcgagt Protein function: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase- dependent and -independent mechanisms. Exhibits antiviral activity against Vif-deficient HIV-1 (PubMed:15152192, PubMed:23001005). After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus- strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. [The UniProt Consortium]