ABI2 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC, A

Length: 1428 Sequence: atggcggagc tgcagatgct gctggaagag gaaatcccgg ggggccgccg ggccctcttc gacagctaca caaatctgga acgggtggcc gattactgcg agaacaacta catacagtca gcagataagc agagagccct agaagaaacc aaagcctaca ccacccaatc cttagcaagt gttgcctatc tgataaacac cttggccaac aatgtcctgc agatgctgga tatccaggca tcccagctac gaaggatgga atcttcaatc aatcatattt cacaaacagt tgatattcat aaagagaaag ttgcaagaag agaaattggt attttgacta ccaataaaaa cacttcaagg acacataaga ttattgctcc agccaacctt gaacgaccag ttcgttatat tagaaaacct attgactata caattctaga tgatattgga catggagtaa aggtgagtac ccagaacatg aagatgggtg ggctgccgcg tacaacacct ccaactcaga agccccctag tccccctatg tcagggaaag ggacacttgg gcggcactcc ccctatcgca cactggagcc agtgcgtcct ccagtggtac caaatgatta cgtacctagc ccaacccgta atatggctcc ctcgcagcag agccctgtga ggacagcttc tgtgaatcaa agaaatcgaa cttacagcag cagtgggagt agtggaggga gccacccaag tagtcggagc agcagtcgag agaacagtgg aagtggtagt gtgggggttc ctattgctgt tcctactcca tctcctccca gtgtctttcc aggtcatcct gtacagttct acagcatgaa taggcctgcc tctcgccata ctcccccaac aatagggggc tcgttgccct atagacgccc tccttccatt acttcacaaa caagccttca gaatcagatg aatggaggac ctttttatag ccagaatcca gtatctcttg ctcctcctcc tccctccatc ctacaggtaa ctcctcagtt acctttaatg ggatttgtgg ccagagtcca agaaaatatt tcagatacac cacctccacc gccacctgtg gaagaaccag tctttgatga gtctccccca cctcctcctc ctccagaaga ttacgaagag gaggaagctg ctgtggttga gtatagtgat ccttatgctg aagaggaccc accgtgggct ccacgttctt acttggaaaa ggttgtggca atttatgact atacaaaaga caaggaagat gagctgtcct ttcaggaagg agccattatt tatgtcatca agaagaatga cgatggttgg tatgagggag ttatgaatgg agtgactggg ctttttcctg ggaattacgt tgagtctatc atgcattatt Protein function: Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation (PubMed:21107423). Acts as regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge (PubMed:7590236, PubMed:8649853, PubMed:10498863). Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain. In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth. Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface. Also required for nascent adherens junction assembly in epithelial cells (PubMed:15572692). [The UniProt Consortium]