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![Etomidate-d5](https://www.biomol.com/media/image/21/21/b1/Cay40297-1_600x600.png)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay40297-1 | 1 mg | - |
6 - 10 business days* |
603.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Etomidate-d5 is intended for use as an internal standard for the quantification of etomidate by... more
Product information "Etomidate-d5"
Etomidate-d5 is intended for use as an internal standard for the quantification of etomidate by GC- or LC-MS. Etomidate is a general anesthetic. It selectively binds to GABAA receptors over voltage-gated sodium channels (Nav) and L-type voltage-gated calcium channels (Cav, IC50s = 15.7, 387, and 950 µM, respectively). Etomidate also inhibits the cytochrome P450 (CYP) isoforms CYP11B1 and CYP11B2 (IC50s = 0.5 and 0.1 nM, respectively), enzymes involved in cortisol and aldosterone biosynthesis, respectively. It inhibits the production of deoxycortisol and 17alpha-hydroxy progesterone (Cay-33154) induced by adrenocorticotropic hormone (ACTH) in dispersed adrenocortical cells isolated from patients with Cushing's syndrome. Etomidate (3 mg/kg) induces anesthesia and increases the minimum convulsive dose of pentylenetetrazole during the recovery period, but also induces myoclonus, in mice. Formulations containing etomidate have been used as general anesthetics.Formal Name: 1-[(1R)-1-(phenyl-d5)ethyl]1H-imidazole-5-carboxylic acid ethyl ester. Synonyms: (+)-Etomidate-d5, d-Etomidate-d5, (R)-Etomidate-d5. Molecular Formula: C14H11D5N2O2. Formula Weight: 249.3. Purity: >99% deuterated forms (d1-d5). Formulation: (Request formulation change), A neat liquid. Solubility: DMF: soluble, DMSO: soluble, Ethanol: soluble, Methanol: soluble. SMILES: O=C(OCC)C1=CN=CN1[C@H](C)C2=C([2H])C([2H])=C([2H])C([2H])=C2[2H]. InChi Code: InChI=1S/C14H16N2O2/c1-3-18-14(17)13-9-15-10-16(13)11(2)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3/t11-/m1/s1/i4D,5D,6D,7D,8D. InChi Key: NPUKDXXFDDZOKR-IYMQPUKBSA-N.
Keywords: | (+)-Etomidate-d5, (R)-Etomidate-d5, d-Etomidate-d5, 1-[(1R)-1-(phenyl-d5)ethyl]1H-imidazole-5-carboxylic acid ethyl ester |
Supplier: | Cayman Chemical |
Supplier-Nr: | 40297 |
Properties
Application: | GC-MS, LC-MS internal standard, quantification, general anesthetic |
MW: | 249.3 D |
Formula: | C14H11D5N2O2 |
Purity: | >99% deuterated forms (d1-d5) |
Format: | Liquid |
Database Information
KEGG ID : | K05175 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
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H Phrases: | H302, H312, H315, H319, H332, H400 |
P Phrases: | P261, P264, P270, P271, P273, P280, P301+310, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P361+364, P362+364, P391, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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