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![Diltiazem-d3 (hydrochloride)](https://www.biomol.com/media/image/93/21/09/Cay39981-1_600x600.png)
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Diltiazem-d3 is intended for use as an internal standard for the quantification of diltiazem by... more
Product information "Diltiazem-d3 (hydrochloride)"
Diltiazem-d3 is intended for use as an internal standard for the quantification of diltiazem by GC- or LC-MS. Diltiazem is an L-type calcium channel inhibitor. It inhibits stretch-induced calcium release in H9c2 rat cardiomyocytes when used at concentrations ranging from 10-1,000 µM. In vivo, diltiazem (100 mg/kg) inhibits angiotensin II-induced increases in systolic blood pressure and aortic aneurysm formation in ApoE-/- mice. It reduces myocardial apoptosis, increases blood flow in ischemic myocardium, and reduces arrhythmias in a dog model of ischemia and reperfusion-induced myocardial infarction. Formulations containing diltiazem have been used in the treatment of hypertension and angina.Formal Name: (2S,3S)-3-(acetyloxy-d3)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one, monohydrochloride. CAS Number: 1217860-13-3. Synonyms: (+)-cis-Diltiazem-d3. Molecular Formula: C22H23D3N2O4S . HCl. Formula Weight: 454.0. Purity: >99% deuterated forms (d1-d3). Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. SMILES: O=C(C([2H])([2H])[2H])O[C@@H](C1=O)[C@H](C(C=C2)=CC=C2OC)SC3=CC=CC=C3N1CCN(C)C.Cl. InChi Code: InChI=1S/C22H26N2O4S.ClH/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3,/h5-12,20-21H,13-14H2,1-4H3,1H/t20-,21+,/m1./s1/i1D3,. InChi Key: HDRXZJPWHTXQRI-SOOXQBGUSA-N.
Keywords: | (+)-cis-Diltiazem-d3, (2S,3S)-3-(acetyloxy-d3)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one, monohydrochloride |
Supplier: | Cayman Chemical |
Supplier-Nr: | 39981 |
Properties
Application: | GC-MS, LC-MS internal standard, quantification, L-type calcium channel inhibitor |
MW: | 454 D |
Formula: | C22H23D3N2O4S . HCl |
Purity: | >99% deuterated forms (d1-d3) |
Format: | Solid |
Database Information
CAS : | 1217860-13-3| Matching products |
KEGG ID : | K04850 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
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H Phrases: | H302, H315, H319 |
P Phrases: | P264, P270, P280, P301+310, P302+352, P305+351+338, P321, P330, P332+313, P337+313, P362+364, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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