Zymosan A

Zymosan A is a glucan derived from the cell wall of S. cerevisiae that activates toll-like receptor 2 (TLR2) and a C-type lectin, dectin-1, on macrophages, monocytes, and dendritic cells to induce inflammatory signaling. It is commonly used to stimulate a sterile inflammatory response in mouse models of sepsis, shock, and peritonitis. In a mouse model of sepsis/shock, a lethal dose of zymosan A (500 mg/kg) in rats induced inflammation and shock leading to death. Zymosan A can also induce biosynthesis of eicosanoids.CAS Number: 58856-93-2. Formulation: (Request formulation change), A powder. Solubility: Chloroform: 100 µg/ml, DMSO: 200 µg/ml, Ethanol: 100 µg/ml.