ZLN024

ZLN024 is an allosteric activator of AMP-activated protein kinase (AMPK) heterotrimers (EC50s = 0.42 and 0.95 µM for alpha1beta1gamma1 and alpha2beta1gamma1, respectively). Activation of AMPK by ZLN024 requires phosphorylation of AMPK on Thr172, and ZLN024 protects Thr172 from dephosphorylation by protein phosphatase 2Calpha. ZLN024 stimulates glucose uptake and fatty acid oxidation in L6 myotubes. In primary hepatocytes, ZLN024 decreases fatty acid synthesis and glucose output. ZLN024 reduces liver triacylglycerol and total cholesterol content and improves glucose tolerance in db/db mice.Formal Name: 2-[[2-(2-bromo-4-methylphenoxy)ethyl]thio]-pyrimidine. CAS Number: 723249-01-2. Molecular Formula: C13H13BrN2OS. Formula Weight: 325.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml, DMSO: 25 mg/ml, Ethanol: 5 mg/ml. lambdamax: 249, 282 nm. SMILES: CC1=CC(Br)=C(OCCSC2=NC=CC=N2)C=C1. InChi Code: InChI=1S/C13H13BrN2OS/c1-10-3-4-12(11(14)9-10)17-7-8-18-13-15-5-2-6-16-13/h2-6,9H,7-8H2,1H3. InChi Key: KWJRSHZSULRJHE-UHFFFAOYSA-N.