YK-11

YK-11 is an androgen receptor partial agonist that activates androgen receptor transcriptional activity in HEK293 cells overexpressing androgen receptors when used at a concentration of 0.1 µM. It induces expression of the androgen receptor target genes FKBP51 and FGF18 in HEK293 cells when used at a concentration of 10 µM. YK-11 accelerates nuclear translocation of androgen receptors without inducing interaction between the androgen receptor N- and C-termini. In C2C12 cells, YK-11 (500 nM) increases expression of the myogenic regulatory factors MyoD, Myf5, and myogenin, as well as follistatin (Fst), and induces myogenic differentiation. YK-11 also accelerates proliferation and mineralization and increases expression of the osteoblast differentiation markers osteoprotegerin and osteocalcin in MC3T3-E1 mouse osteoblast cells.Formal Name: (20E)-17alpha,20-[(1-methoxyethylidene)bis(oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic acid, methyl ester. CAS Number: 1370003-76-1. Molecular Formula: C25H34O6. Formula Weight: 430.5. Purity: >95% (mixture of diastereomers). Formulation: (Request formulation change), A crystalline solid. Solubility: Acetonitrile: 1 mg/ml, Ethanol: 1 mg/ml, Methanol: 1 mg/ml. lambdamax: 242 nm. SMILES: O=C(OC)/C=C1OC(OC)(C)O[C@@]2/1CC[C@@]3([H])[C@]4([H])CCC5=CC(CC[C@]5([H])[C@@]4([H])CC[C@@]32C)=O. InChi Code: InChI=1S/C25H34O6/c1-23-11-9-18-17-8-6-16(26)13-15(17)5-7-19(18)20(23)10-12-25(23)21(14-22(27)28-3)30-24(2,29-4)31-25/h13-14,17-20H,5-12H2,1-4H3/b21-14+/t17-,18+,19+,20-,23-,24?,25+/m0/s1. InChi Key: KCQHQCDHFVGNMK-PQUNLUOYSA-N.