Xestospongin C

Xestospongin C is a marine natural product which was first isolated from Pacific basin sponges, and noted to have vasodilatory properties. Xestospongin C antagonizes the calcium-releasing action of inositol-1,4,5-trisphosphate (IP3) at the receptor level. Inositol phosphates are important signal transduction messengers acting via IP3 receptors to promote the mobilization of Ca2+ from intracellular stores. Xestospongin C blocks the increase in intracellular calcium in vascular smooth muscle cells completely at a concentration of 25 µM. Xestospongin C also inhibits the sarcoplasmic reticulum Ca2+ ATPase pump at concentrations of 700 nM.Formal Name: [1R-(1R,4aR,11R,12aS,13S,16aS,23R,24aS)]-eicosahydro-5H,17H-1,23:11,13-diethano-2H,14H-[1,11]dioxacycloeicosino[2,3-b:12,13-b1]dipyridine. CAS Number: 88903-69-9. Synonyms: Araguspongine E, XeC. Molecular Formula: C28H50N2O2. Formula Weight: 446.7. Purity: >90%. Formulation: (Request formulation change), A clear film. Solubility: Chloroform: Soluble, Ethyl Acetate: Soluble, Methyl Acetate: Soluble. SMILES: [H][C@@]1(N2CCC3)[C@H]3CCCCCC[C@H]4O[C@]5([H])N(CCC[C@H]5CCCCCC[C@H](CC2)O1)CC4. InChi Code: InChI=1S/C28H50N2O2/c1-3-7-15-25-17-21-30-20-10-14-24(28(30)31-25)12-6-2-4-8-16-26-18-22-29-19-9-13-23(11-5-1)27(29)32-26/h23-28H,1-22H2/t23-,24+,25-,26-,27+,28+/m1/s1. InChi Key: PQYOPBRFUUEHRC-HCKQMYSWSA-N.