VL422

VL422 is an ionizable cationic lipid. It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of CRISPR complementary single-guide RNA (sgRNA) and Cas9 mRNA for gene editing in vitro and in vivo. LNPs containing VL422 and encapsulating Cas9 mRNA and sgRNA targeting the gene encoding angiopoietin-related protein 3 (ANGPTL3), a protein whose loss-of-function decreases LDL, HDL, and cholesterol plasma levels, induce a deletion in a premature stop codon in ANGPTL3 in the livers of cynomolgus monkeys.Formal Name: octanedioic acid, 1,1'-[2-[[[[3-(diethylamino)propoxy]carbonyl]oxy]methyl]-1,3-propanediyl] 8,8'-bis(1-octylnonyl) ester. CAS Number: 2765519-47-7. Molecular Formula: C62H117NO11. Formula Weight: 1052.6. Purity: >95%. Formulation: (Request formulation change), A solution in ethanol. Solubility: Chloroform: Soluble. SMILES: CCCCCCCCC(CCCCCCCC)OC(CCCCCCC(OCC(COC(OCCCN(CC)CC)=O)COC(CCCCCCC(OC(CCCCCCCC)CCCCCCCC)=O)=O)=O)=O. InChi Code: InChI=1S/C62H117NO11/c1-7-13-17-21-25-33-42-56(43-34-26-22-18-14-8-2)73-60(66)48-39-31-29-37-46-58(64)70-52-55(54-72-62(68)69-51-41-50-63(11-5)12-6)53-71-59(65)47-38-30-32-40-49-61(67)74-57(44-35-27-23-19-15-9-3)45-36-28-24-20-16-10-4/h55-57H,7-54H2,1-6H3. InChi Key: LUQLMJLIEUBIFP-UHFFFAOYSA-N.