VL422

VL422
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay39874-1 1 mg -

6 - 10 business days*

95.00€
Cay39874-5 5 mg -

6 - 10 business days*

449.00€
Cay39874-10 10 mg -

6 - 10 business days*

756.00€
 
VL422 is an ionizable cationic lipid. It has been used in the generation of lipid nanoparticles... more
Product information "VL422"
VL422 is an ionizable cationic lipid. It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of CRISPR complementary single-guide RNA (sgRNA) and Cas9 mRNA for gene editing in vitro and in vivo. LNPs containing VL422 and encapsulating Cas9 mRNA and sgRNA targeting the gene encoding angiopoietin-related protein 3 (ANGPTL3), a protein whose loss-of-function decreases LDL, HDL, and cholesterol plasma levels, induce a deletion in a premature stop codon in ANGPTL3 in the livers of cynomolgus monkeys.Formal Name: octanedioic acid, 1,1'-[2-[[[[3-(diethylamino)propoxy]carbonyl]oxy]methyl]-1,3-propanediyl] 8,8'-bis(1-octylnonyl) ester. CAS Number: 2765519-47-7. Molecular Formula: C62H117NO11. Formula Weight: 1052.6. Purity: >95%. Formulation: (Request formulation change), A solution in ethanol. Solubility: Chloroform: Soluble. SMILES: CCCCCCCCC(CCCCCCCC)OC(CCCCCCC(OCC(COC(OCCCN(CC)CC)=O)COC(CCCCCCC(OC(CCCCCCCC)CCCCCCCC)=O)=O)=O)=O. InChi Code: InChI=1S/C62H117NO11/c1-7-13-17-21-25-33-42-56(43-34-26-22-18-14-8-2)73-60(66)48-39-31-29-37-46-58(64)70-52-55(54-72-62(68)69-51-41-50-63(11-5)12-6)53-71-59(65)47-38-30-32-40-49-61(67)74-57(44-35-27-23-19-15-9-3)45-36-28-24-20-16-10-4/h55-57H,7-54H2,1-6H3. InChi Key: LUQLMJLIEUBIFP-UHFFFAOYSA-N.
Keywords: octanedioic acid, 1,1'-[2-[[[[3-(diethylamino)propoxy]carbonyl]oxy]methyl]-1,3-propanediyl] 8,8'-bis(1-octylnonyl) ester
Supplier: Cayman Chemical
Supplier-Nr: 39874

Properties

Application: Ionizable cationic lipid, LNP formation
MW: 1052.6 D
Formula: C62H117NO11
Purity: >95%
Format: Solution

Database Information

CAS : 2765519-47-7| Matching products

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H225, H319, H333
P Phrases: P210, P233, P240, P241, P242, P243, P264, P280, P304, P312, P303+P361+P353, P305+P351+P338, P337+P313, P370+P378, P403+P235, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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