TK05

TK05 is an inhibitor of leukotriene C4 (LTC4) synthase (IC50 = 95 nM). It is selective for LTC4 synthase over microsomal prostaglandin E synthase-1 (mPGES-1), microsomal glutathione S-transferase 2 (GST2), and 5-lipoxygenase (5-LO) at 10 µM. TK05 (1 µM) inhibits LTC4 synthase in Mono-Mac-6 leukemia cells and isolated human eosinophils, monocytes, and platelets but not cord blood-derived mast cells. In vivo, TK05 (0.12 and 6 mg/kg) prevents zymosan A-induced increases in peritoneal fluid levels of LTE4 and LTB4 in mice.Formal Name: 5-[[5-[(4-chlorophenyl)(cyclopropylmethyl)amino]-2-pyridinyl]carbonyl]-2-(4-methoxybenzoyl)-benzoic acid. CAS Number: 1245734-61-5. Molecular Formula: C31H25ClN2O5. Formula Weight: 541.0. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Methanol: soluble. SMILES: OC(C1=CC(C(C2=NC=C(N(CC3CC3)C4=CC=C(Cl)C=C4)C=C2)=O)=CC=C1C(C5=CC=C(OC)C=C5)=O)=O. InChi Code: InChI=1S/C31H25ClN2O5/c1-39-25-12-4-20(5-13-25)29(35)26-14-6-21(16-27(26)31(37)38)30(36)28-15-11-24(17-33-28)34(18-19-2-3-19)23-9-7-22(32)8-10-23/h4-17,19H,2-3,18H2,1H3,(H,37,38). InChi Key: GRDDFJXOEAJYCT-UHFFFAOYSA-N.