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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay19793-500 | 500 µg | - |
6 - 10 business days* |
153.00€
|
|||
Cay19793-1 | 1 mg | - |
6 - 10 business days* |
291.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
TK05 is an inhibitor of leukotriene C4 (LTC4) synthase (IC50 = 95 nM). It is selective for LTC4... more
Product information "TK05"
TK05 is an inhibitor of leukotriene C4 (LTC4) synthase (IC50 = 95 nM). It is selective for LTC4 synthase over microsomal prostaglandin E synthase-1 (mPGES-1), microsomal glutathione S-transferase 2 (GST2), and 5-lipoxygenase (5-LO) at 10 µM. TK05 (1 µM) inhibits LTC4 synthase in Mono-Mac-6 leukemia cells and isolated human eosinophils, monocytes, and platelets but not cord blood-derived mast cells. In vivo, TK05 (0.12 and 6 mg/kg) prevents zymosan A-induced increases in peritoneal fluid levels of LTE4 and LTB4 in mice.Formal Name: 5-[[5-[(4-chlorophenyl)(cyclopropylmethyl)amino]-2-pyridinyl]carbonyl]-2-(4-methoxybenzoyl)-benzoic acid. CAS Number: 1245734-61-5. Molecular Formula: C31H25ClN2O5. Formula Weight: 541.0. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Methanol: soluble. SMILES: OC(C1=CC(C(C2=NC=C(N(CC3CC3)C4=CC=C(Cl)C=C4)C=C2)=O)=CC=C1C(C5=CC=C(OC)C=C5)=O)=O. InChi Code: InChI=1S/C31H25ClN2O5/c1-39-25-12-4-20(5-13-25)29(35)26-14-6-21(16-27(26)31(37)38)30(36)28-15-11-24(17-33-28)34(18-19-2-3-19)23-9-7-22(32)8-10-23/h4-17,19H,2-3,18H2,1H3,(H,37,38). InChi Key: GRDDFJXOEAJYCT-UHFFFAOYSA-N.
Keywords: | 5-[[5-[(4-chlorophenyl)(cyclopropylmethyl)amino]-2-pyridinyl]carbonyl]-2-(4-methoxybenzoyl)-benzoic acid |
Supplier: | Cayman Chemical |
Supplier-Nr: | 19793 |
Properties
Application: | LTC4 synthase inhibitor |
MW: | 541 D |
Formula: | C31H25ClN2O5 |
Purity: | >95% |
Format: | Solid |
Database Information
CAS : | 1245734-61-5| Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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