Tafluprost ethyl ester

Analogs of prostaglandin F2alpha (PGF2alpha), which act primarily at the FP receptor, have been approved for the treatment of glaucoma. Tafluprost (free acid) (Cay-10005439) is a PGF2alpha analog which acts as a potent FP receptor agonist (Ki = 0.4 nM). Tafluprost ethyl ester is a form of tafluprost which may have increased lipid solubility compared to the free acid. In addition, the ethyl ester form may demonstrate improved uptake into tissues and thus lower the effective concentration.Formal Name: 15,15-difluoro-9alpha,11alpha-dihydroxy-16-phenoxy-17,18,19,20-tetranor-prosta-5Z,13E-dien-1-oic acid, ethyl ester. CAS Number: 209860-89-9. Synonyms: AFP 175. Molecular Formula: C24H32F2O5. Formula Weight: 438.5. Purity: >98%. Formulation: (Request formulation change), 10% wt/wt in ethanol. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml. lambdamax: 217 nm. SMILES: O[C@@H]1[C@H](C/C=C\CCCC(OCC)=O)[C@@H](/C=C/C(F)(F)COC2=CC=CC=C2)[C@H](O)C1. InChi Code: InChI=1S/C24H32F2O5/c1-2-30-23(29)13-9-4-3-8-12-19-20(22(28)16-21(19)27)14-15-24(25,26)17-31-18-10-6-5-7-11-18/h3,5-8,10-11,14-15,19-22,27-28H,2,4,9,12-13,16-17H2,1H3/b8-3-,15-14+/t19-,20-,21+,22-/m1/s1. InChi Key: SPWJIEVPQKMQPO-MSHHKXPZSA-N.