Sterculic Acid

Sterculic acid is a cyclopropene fatty acid that has been found in S. foetida. It is an inhibitor of Delta9-desaturase that decreases 9(Z)-myristoleic acid (Cay-9002461) and increases oleic acid (Cay-90260) and 9(Z),11(E)-conjugated linoleic acid (Cay-90140) levels in the milk of lactating ewes when administered at a dose of 0.5 g per day. It also inhibits endoplasmic reticulum stress induced by 7-keto cholesterol (Cay-16339) in ARPE-19 cells when used at a concentration of 1 µM and prevents the formation of choroidal neovascularization when applied to eyes at concentrations of 0.1 to 10 mM in a rat model of macular degeneration induced by laser injury. Sterculic acid binds to a variety of kinases, including calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2), mammalian sterile20-related kinase 3 (MST3), and p90 ribosomal S5 kinase 4 (RSK4). [Matreya, LLC. Catalog No. 1235]Formal Name: 2-octyl-1-cyclopropene-1-octanoic acid. CAS Number: 738-87-4. Synonyms: FA 19:2. Molecular Formula: C19H34O2. Formula Weight: 294.5. Purity: >98%. Formulation: (Request formulation change), A liquid. Solubility: Chloroform: soluble, Ether: soluble, Hexane: soluble, Methanol: soluble. SMILES: CCCCCCCCC1=C(CCCCCCCC(O)=O)C1. InChi Code: InChI=1S/C19H34O2/c1-2-3-4-5-7-10-13-17-16-18(17)14-11-8-6-9-12-15-19(20)21/h2-16H2,1H3,(H,20,21). InChi Key: PQRKPYLNZGDCFH-UHFFFAOYSA-N.