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Stearoyl serotonin is a hybrid molecule patterned after arachidonoyl serotonin (Cay-70665). Arachidonoyl serotonin is a dual antagonist of fatty acid amide hydrolase (FAAH) and the transient receptor potential vanilloid-type 1 (TRPV1) channel, reducing both acute and chronic peripheral pain. The effects of replacing the arachidonoyl portion with the saturated 18-carbon stearoyl moiety have not been studied. However, replacement of arachidonate with saturated 11- or 12-carbon fatty acids produces compounds that potently inhibit capsaicin-induced TRPV1 channel activation (IC50 = 0.76 µM) without blocking FAAH-mediated hydrolysis of arachidonoyl ethanolamine (IC50 > 50 µM).Formal Name: N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-octadecanamide. CAS Number: 67964-87-8. Molecular Formula: C28H46N2O2. Formula Weight: 442.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 2.5 mg/ml. lambdamax: 279 nm. SMILES: O=C(NCCC1=CNC2=CC=C(O)C=C12)CCCCCCCCCCCCCCCCC. InChi Code: InChI=1S/C28H46N2O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(32)29-21-20-24-23-30-27-19-18-25(31)22-26(24)27/h18-19,22-23,30-31H,2-17,20-21H2,1H3,(H,29,32). InChi Key: FKWHKBXVLNKTGT-UHFFFAOYSA-N.
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