SLM6031434

SLM6031434 is an inhibitor of sphingosine kinase 2 (SPHK2) (Ki = 0.4 µM for the recombinant mouse enzyme). It is selective for SPHK2 over SPHK1 (Kis = >20 µM). It decreases sphingosine-1-phosphate (S1P, Cay-62570) and increases sphingosine levels in U937 monocytic leukemia cells in a concentration-dependent manner. SLM6031434 (5 mg/kg) reduces blood S1P levels in Sphk1-/-, but not Sphk2-/-, mice. SLM6031434 also increases blood S1P levels in wild-type mice and rats.Formal Name: (2S)-2-[3-[4-(octyloxy)-3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-pyrrolidinecarboximidamide. CAS Number: 1897379-33-7. Molecular Formula: C22H30F3N5O2. Formula Weight: 453.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. lambdamax: 258 nm. SMILES: N=C(N)N1CCC[C@H]1C2=NC(C3=CC(C(F)(F)F)=C(C=C3)OCCCCCCCC)=NO2. InChi Code: InChI=1S/C22H30F3N5O2/c1-2-3-4-5-6-7-13-31-18-11-10-15(14-16(18)22(23,24)25)19-28-20(32-29-19)17-9-8-12-30(17)21(26)27/h10-11,14,17H,2-9,12-13H2,1H3,(H3,26,27)/t17-/m0/s1. InChi Key: ACUOAECMLLBZNL-KRWDZBQOSA-N.