RP 70676

RP 70676 is an inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT, IC50 = 44 nM for the rabbit enzyme). It reduces plasma and arterial cholesterol levels in rabbits when administered at a dose of 1 mg/kg.Formal Name: 1-[5-[(4,5-diphenyl-1H-imidazol-2-yl)thio]pentyl]-3,5-dimethyl-1H-pyrazole. CAS Number: 136609-26-2. Molecular Formula: C25H28N4S. Formula Weight: 416.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Soluble, DMSO: Soluble. SMILES: CC1=CC(C)=NN1CCCCCSC2=NC(C3=CC=CC=C3)=C(C4=CC=CC=C4)N2. InChi Code: InChI=1S/C25H28N4S/c1-19-18-20(2)29(28-19)16-10-5-11-17-30-25-26-23(21-12-6-3-7-13-21)24(27-25)22-14-8-4-9-15-22/h3-4,6-9,12-15,18H,5,10-11,16-17H2,1-2H3,(H,26,27). InChi Key: UUPITLNVYVCTFW-UHFFFAOYSA-N.