Rosmanol

Rosmanol is a polyphenol that has been found in R. officinalis and has diverse biological activities. It is an inhibitor of alpha-glucosidase and alpha-amylase (IC50s = 16.4 and 40.9 µg/ml, respectively) and has antioxidant activity in a Trolox equivalent absorbance capacity (TEAC) assay. Rosmanol activates the mitochondrial and death receptor apoptosis pathways and induces apoptosis in COLO 205 colorectal cancer cells (IC50 = ~42 µM). It also inhibits LPS-induced production of prostaglandin E2 (PGE2), as well as reduces the activity of NF-kappaB, inducible nitric oxide synthase (iNOS), and COX-2 induced by LPS, in RAW 264.7 macrophages when used at concentrations of 2.5 and 5 µM. Rosmanol (30-100 mg/kg) increases the latency to tail withdrawal in the hot plate test, decreases immobility in the forced swim test, and increases the time spent in the open arms of the elevated plus maze in mice, indicating antinociceptive, antidepressant-like, and anxiolytic-like activities, respectively.Formal Name: (4aR,9S,10S,10aS)-1,3,4,9,10,10a-hexahydro-5,6,9-trihydroxy-1,1-dimethyl-7-(1-methylethyl)-2H-10,4a-(epoxymethano)phenanthren-12-one. CAS Number: 80225-53-2. Molecular Formula: C20H26O5. Formula Weight: 346.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. SMILES: O=C1[C@@]23C4=C(O)C(O)=C(C(C)C)C=C4[C@@H]([C@@H](O1)[C@@]2([H])C(C)(CCC3)C)O. InChi Code: InChI=1S/C20H26O5/c1-9(2)10-8-11-12(15(23)13(10)21)20-7-5-6-19(3,4)17(20)16(14(11)22)25-18(20)24/h8-9,14,16-17,21-23H,5-7H2,1-4H3/t14-,16+,17-,20-/m0/s1. InChi Key: LCAZOMIGFDQMNC-FORWCCJISA-N. Origin: Plant/Salvia officinalis.