Prostaglandin E2-PEG11-biotin

PGE2 is the major eicosanoid product of cyclooxygenase-1 and 2 in epithelial cells, leukocytes, reproductive tissues, and many others. PGE2 contracts smooth muscle, protects the gastric mucosa, modulates immune function, and regulates fertility and implantation. PGE2 acts through at least four G-protein coupled receptors, EP1-EP4. PGE2-PEG11-biotin is an affinity probe which allows PGE2 to be detected or immobilized using the biotin ligand. The PEG11 moiety serves to separate the biotin linker from PGE2 with a hydrophilic spacer. It is thus a tool to be used in the elucidation of PGE2 actions or interactions in aqueous solutions.Formal Name: 11alpha,15S-dihydroxy-9-oxo-prosta-52,13E-dien-1-oyl-polyethylene glycol 11-N'-biotinoyl-1,5-diaminopentane. Synonyms: PGE2-PEG11-biotin. Molecular Formula: C54H96N4O17S. Formula Weight: 1105.4. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 50 mg/ml, DMSO: 50 mg/ml, Ethanol: 50 mg/ml, PBS (pH 7.2): 1 mg/ml. SMILES: O=C1[C@H](C/C=C\CCCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCCC[C@H]2SC[C@@](N3)([H])[C@]2([H])NC3=O)=O)=O)[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C1. InChi Code: InChI=1S/C54H96N4O17S/c1-2-3-6-11-44(59)16-17-46-45(48(60)42-49(46)61)12-7-4-5-8-14-51(62)55-18-20-65-22-24-67-26-28-69-30-32-71-34-36-73-38-40-75-41-39-74-37-35-72-33-31-70-29-27-68-25-23-66-21-19-56-52(63)15-10-9-13-50-53-47(43-76-50)57-54(64)58-53. InChi Key: GJDVPBZZICGDDC-FLSODGMCSA-N.