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Phellopterin is a furanocoumarin that has been found in A. dahurica and has diverse biological activities. It is an antagonist of GABAA receptors (IC50 = 360 nM for the rat receptor). Phellopterin (20 µM) decreases LPS-induced secretion of prostaglandin E2 (PGE2, Cay-14010) from primary rat peritoneal macrophages. Topical application of phellopterin (1.2 µg/g) accelerates wound healing in a mouse model of diabetes induced by streptozotocin (Cay-13104). It increases the levels of mRNA encoding sirtuin 1 (Sirt1) and decreases mRNA encoding intracellular adhesion molecule-1 (Icam-1) in epithelium isolated from mice in the same model.Formal Name: 7-butyl-5-hydroxy-2-methyl-2-(4-methyl-3-penten-1-yl)-2H-1-benzopyran-6-carboxylic acid. CAS Number: 2543-94-4. Synonyms: NSC 152469. Molecular Formula: C17H16O5. Formula Weight: 300.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: Soluble, Methanol: Soluble. SMILES: COC(C1=C2OC(C=C1)=O)=C(C=CO3)C3=C2OC/C=C(C)\C. InChi Code: InChI=1S/C17H16O5/c1-10(2)6-8-21-17-15-12(7-9-20-15)14(19-3)11-4-5-13(18)22-16(11)17/h4-7,9H,8H2,1-3H3. InChi Key: BMLZFLQMBMYVHG-UHFFFAOYSA-N. Origin: Plant/Saposhnikovia divaricata.
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