PAMAM Dendrimer G4.0 Succinamic Acid (water solution)

PAMAM dendrimer G4.0 succinamic acid (PAMAM G4.0-SAH) is a polyamidoamine (PAMAM) dendrimer with succinamic acid termini that has been used as a drug delivery system in vitro and in vivo., It is approximately 45 Å in diameter in PBS and has 64 surface groups., PAMAM G4.0-SAH (10 µM) inhibits plaque formation induced by Middle East respiratory syndrome coronavirus (MERS-CoV) in infected Vero cells. It is active against S. aureus. Lipid-dendrimer hybrid nanoparticles containing PAMAM G4.0-SAH and encapsulating the glycopeptide antibiotic vancomycin (Cay-15327) are active against S. aureus and methicillin-resistant S. aureus (MRSA). In vivo, PAMAM G4.0-SAH conjugated to the monosaccharide sialic acid, also known as N-acetylneuraminic acid (Neu5Ac), prevents infection by the influenza A subtype H3N2 in a mouse model of pneumonitis when administered at a dose of 9 µg/g.Synonyms: PAMAM G4.0 Succinamic Acid, Polyamidoamine Dendrimer G4.0 Succinamic Acid. Formula Weight: 20615.0. Formulation: (Request formulation change), A solution in water. Solubility: Water: Soluble.