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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay39108-500 | 500 mg | - |
6 - 10 business days* |
294.00€
|
|||
Cay39108-1 | 1 g | - |
6 - 10 business days* |
560.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
PAMAM dendrimer G3.5 carboxylate (PAMAM G3.5) is a polyamidoamine (PAMAM) dendrimer with... more
Product information "PAMAM Dendrimer G3.5 Carboxylate (sodium salt) (water solution)"
PAMAM dendrimer G3.5 carboxylate (PAMAM G3.5) is a polyamidoamine (PAMAM) dendrimer with carboxylate termini that has been used as a drug delivery system in vitro and in vivo. It is approximately 66.1 Å in diameter in water and has 48 surface groups. PAMAM G3.5 is active against E. coli (IC50 = 22 mg/ml) and increases the mitochondrial membrane potential of isolated rat liver mitochondria when used at concentrations ranging from 10 to 50 µM. Unlike amine-terminated PAMAM G4.0, PAMAM G3.5 (20 µM) is not toxic to zebrafish embryos. A fluorescently labeled form of PAMAM G3.5 enters Caco-2 cells via dynamin-, clathrin-, and caveolin-mediated endocytosis. Conjugates of PAMAM G3.5 with the active fragment of the DNA cross-linking agent oxaliplatin (Cay-13106) are cytotoxic to A2780 ovarian, MCF-7 breast, and Caco-2 colon cancer cells and BJ fibroblasts (IC50s = 0.08, 4.1, 0.39, and 3 µM, respectively). PAMAM G3.5 in complex with the topoisomerase I inhibitor camptothecin (Cay-11694) increases the oral bioavailability of camptothecin in mice.CAS Number: 192948-77-9. Synonyms: PAMAM G3.5 Carboxylate, Polyamidoamine Dendrimer G3.5 Carboxylate. Molecular Formula: [NH2(CH2)2NH2]:(G=3.5),dendri PAMAM(NHCH2CH2COONa)64. Formula Weight: 12927.7. Formulation: (Request formulation change), A solution in water. Solubility: Water: Soluble.
Keywords: | PAMAM G3.5 Carboxylate, Polyamidoamine Dendrimer G3.5 Carboxylate |
Supplier: | Cayman Chemical |
Supplier-Nr: | 39108 |
Properties
Application: | Carboxylate-terminated PAMAM dendrimer |
MW: | 12927.7 D |
Formula: | [NH2(CH2)2NH2]:(G=3.5),dendri PAMAM(NHCH2CH2COONa)64 |
Format: | Solution |
Database Information
CAS : | 192948-77-9| Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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