PAMAM Dendrimer G3.0 Succinamic Acid (water solution)

PAMAM dendrimer G3.0 succinamic acid (PAMAM G3.0 succinamic acid) is a polyamidoamine (PAMAM) dendrimer with succinamic acid termini that has been used as a drug delivery system in vivo. It is approximately 35 Å in diameter in PBS and has 32 surface groups. PAMAM G3.0 succinamic acid (10 µM) inhibits plaque formation induced by Middle East respiratory syndrome coronavirus (MERS-CoV) in infected Vero cells. It is active against S. aureus. Intravenous administration of PAMAM G3.0 succinamic acid conjugated to the tubulin polymerization inhibitor combretastatin A4 (combrestatin A4, Cay-10007412) increases intratumoral necrosis and decreases intratumoral blood flow in an orthotopic U251 glioma rat xenograft model.Synonyms: PAMAM G3.0 Succinamic Acid, Polyamidoamine Dendrimer G3.0 Succinamic Acid. Formula Weight: 10109.0. Formulation: (Request formulation change), A solution in water. Solubility: Water: Soluble.