PAMAM Dendrimer G3.0 Amidoethanol (water solution)

PAMAM dendrimer G3.0 amidoethanol (PAMAM G3.0 amidoethanol) is a polyamidoamine (PAMAM) dendrimer with hydroxyl termini. It is approximately 30 Å in diameter in PBS and has 32 surface groups. PAMAM G3.0 amidoethanol is an antagonist for the pore-forming channels anthrax protective antigen 63 (PA63) in lipid membranes (IC50 = 44.9 nM). It inhibits aggregation of amylin containing a serine-to-glycine substitution at position 20 (amylinS20G) in a concentration-dependent manner and amylinS20G-induced toxicity in MIN6-K8 and NIT-1 pancreatic beta-cells at 6 µM. Topical application of PAMAM G3.0 amidoethanol (1 mg/ml) encapsulating the synthetic glucocorticoid dexamethasone (Cay-11015) increases the levels of dexamethasone in the sclera, conjunctiva, and cornea in isolated rabbit eyes. It reduces tail growth in C. riparius larvae and induces DNA damage in a comet assay using C. riparius larval homogenates when used at concentrations of 10 or 100 ppm.Synonyms: PAMAM 3.0 Amidoethanol, Polyamidoamine Dendrimer G3.0 Amidoethanol. Molecular Formula: [NH2(CH2)2NH2]:(G=3),dendri PAMAM(NHCH2CH2OH)32. Formula Weight: 6940.4. Formulation: (Request formulation change), A solution in water. Solubility: Water: soluble.