PAMAM Dendrimer G0.0 Amine (water solution)

PAMAM dendrimer G0.0 amine (PAMAM G0.0) is the polyamidoamine (PAMAM) core with amine termini on which other PAMAM dendrimers are synthesized. It is approximately 15 Å in diameter and has 4 surface groups. PAMAM G0.0 is an antagonist for the pore-forming channels anthrax toxin protective antigen 63 (PA63, IC50 = 231 nM) and C. botulinum C2 toxin subunit C2IIa (IC50 = 940 nM) in lipid membranes. It reduces C2 toxin-induced death in HeLa cells when used at concentrations of 10 and 20 µM. PAMAM G0.0 is a chelator of nickel. In complex with polysulfone membrane-bound chitosan, PAMAM G0.0 selectively captures and stores carbon dioxide (CO2) over nitrogen (N2) in a gas-feed system. PAMAM G0.0 has been used in the synthesis of PAMAM dendrimer G0.5 carboxylate (Cay-39104) and PAMAM dendrimer G1.0 amine (Cay-39054).Formal Name: 3,3',3'',3'''-(1,2-ethanediyldinitrilo)tetrakis[N-(2-aminoethyl)-propanamide. CAS Number: 155773-72-1. Synonyms: PAMAM G0.0, Polyamidoamine Dendrimer G0.0. Molecular Formula: C22H48N10O4. Formula Weight: 516.7. Formulation: (Request formulation change), A solution in water. Solubility: Water: Soluble. SMILES: O=C(NCCN)CCN(CCC(NCCN)=O)CCN(CCC(NCCN)=O)CCC(NCCN)=O. InChi Code: InChI=1S/C22H48N10O4/c23-5-9-27-19(33)1-13-31(14-2-20(34)28-10-6-24)17-18-32(15-3-21(35)29-11-7-25)16-4-22(36)30-12-8-26/h1-18,23-26H2,(H,27,33)(H,28,34)(H,29,35)(H,30,36). InChi Key: SENLDUJVTGGYIH-UHFFFAOYSA-N.