Oxfenicine

Oxfenicine is an inhibitor of carnitine palmitoyltransferase 1 (CPT1) and a prodrug form of 4-hydroxyphenylglyoxylic acid. Oxfenicine is transaminated to 4-hydroxyphenylglyoxylic acid by branched-chain amino acid aminotransferase in rat heart homogenates. It inhibits fatty acid oxidation and increases carbohydrate oxidation in isolated rat hearts perfused with palmitate (Cay-10010279), glucose, and insulin. Oxfenicine increases the ex vivo activity of cardiac pyruvate dehydrogenase (PDH) in rats with an ED50 value of 0.3 mmol/kg. It reduces increases in plasma levels of lactate and lactate dehydrogenase 1 (LDH-1), markers of ischemic injury, in a dog model of microsphere-induced coronary ischemia when administered at a dose of 0.1 mmol/kg.Formal Name: alphaS-amino-4-hydroxy-benzeneacetic acid. CAS Number: 32462-30-9. Synonyms: 4-hydroxy-L-Phenylglycine, p-hydroxy-L-Phenylglycine, UK 25842. Molecular Formula: C8H9NO3. Formula Weight: 167.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: slightly soluble, PBS (pH 7.2): slightly soluble. lambdamax: 227 nm. SMILES: OC([C@H](C1=CC=C(C=C1)O)N)=O. InChi Code: InChI=1S/C8H9NO3/c9-7(8(11)12)5-1-3-6(10)4-2-5/h1-4,7,10H,9H2,(H,11,12)/t7-/m0/s1. InChi Key: LJCWONGJFPCTTL-ZETCQYMHSA-N.