Ononin

Ononin is a glycoside isoflavone that has been found in soybeans and A. mongholicus and has anti-inflammatory and neuroprotective activities. Ononin (5 µM) inhibits LPS-induced production of nitrite, prostaglandin E2 (PGE2, Cay-14010), and the pro-inflammatory cytokines IL-1beta, IL-6, and TNF-alpha by RAW 264.7 macrophages. It also inhibits glutamate-induced toxicity in rat adrenal PC12 cells when used at a concentration of 0.025 µg/ml.Formal Name: 7-(beta-D-glucopyranosyloxy)-3-(4-methoxyphenyl)-4H-1-benzopyran-4-one. CAS Number: 486-62-4. Synonyms: Formononetin 7-O-beta-D-Glucopyranoside, Formononetin Glucoside, Formononetin 7-O-Glucoside. Molecular Formula: C22H22O9. Formula Weight: 430.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: Partially soluble, PBS (pH 7.2): 0.25 mg/ml. lambdamax: 233, 262 nm. SMILES: O=C1C2=CC=C(O[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O3)C=C2OC=C1C4=CC=C(OC)C=C4. InChi Code: InChI=1S/C22H22O9/c1-28-12-4-2-11(3-5-12)15-10-29-16-8-13(6-7-14(16)18(15)24)30-22-21(27)20(26)19(25)17(9-23)31-22/h2-8,10,17,19-23,25-27H,9H2,1H3/t17-,19-,20+,21-,22-/m1/s1. InChi Key: MGJLSBDCWOSMHL-MIUGBVLSSA-N. Origin: Plant/Astragalus membranaceus (Fisch.) Bunge.