Oleoyl-L-carnitine-d3 (chloride)

Oleoyl-L-carnitine-d3 is intended for use as an internal standard for the quantification of oleoyl-L-carnitine (Cay-26557, Cay-39014) by GC- or LC-MS. Oleoyl-L-carnitine is a long-chain acylcarnitine and an inhibitor of glycine transporter 2 (GlyT2, IC50 = 340 nM). It is selective for GlyT2 over GlyT1 (IC50 = >10,000 nM). Plasma levels of oleoyl-L-carnitine are increased in patients with chronic kidney disease or end-stage renal disease receiving incident hemodialysis and these are associated with cardiovascular mortality.Formal Name: (R)-3-carboxy-N,N-dimethyl-N-(methyl-d3)-2-(oleoyloxy)propan-1-aminium, monochloride. Synonyms: CAR 18:1-d3, C18:1 Carnitine-d3, L-Carnitine octadecanoyl ester-d3, L-Carnitine oleoyl ester-d3, Octadecanoyl-L-carnitine-d3, L-Octadecanoylcarnitine-d3, L-Oleoylcarnitine-d3. Molecular Formula: C25H45D3NO4 . Cl. Formula Weight: 465.1. Purity: >99% deuterated forms (d1-d3). Formulation: (Request formulation change), A solid. Solubility: DMF: 20 mg/ml, DMSO: 14 mg/ml, Ethanol: 20 mg/ml. SMILES: OC(C[C@H](C[N+](C([2H])([2H])[2H])(C)C)OC(CCCCCCC/C=C\CCCCCCCC)=O)=O.[Cl-]. InChi Code: InChI=1S/C25H47NO4.ClH/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4,/h12-13,23H,5-11,14-22H2,1-4H3,1H/b13-12-,/t23-,/m1./s1/i2D3,. InChi Key: JPDKUMDAMZLOJR-CQZOHPAWSA-N. Side Chain Carbon Sum: 18:1.