Norursodeoxycholic Acid

Norursodeoxycholic acid (norUDCA) is a bile acid and the C23 homolog of UDCA (Cay-15121). Unlike UDCA, norUDCA does not undergo conjugation to taurine or glycine and is secreted in an unchanged form, as trihydroxy derivatives, or as sulfate or glucuronide conjugates. Dietary administration of norUDCA (0.5% w/w) decreases serum levels of alanine aminotransferase (ALT) and alkaline phosphatase, markers of cholestasis, periductal fibrosis, and hepatic hydroxyproline content in an Mdr2-/- mouse model of sclerosing cholangitis.Formal Name: (3alpha,5beta,7beta)-3,7-dihydroxy-24-norcholan-23-oic acid. CAS Number: 99697-24-2. Synonyms: norUDCA, 24-Norursodeoxycholic Acid, Nourcholic Acid. Molecular Formula: C23H38O4. Formula Weight: 378.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. SMILES: C[C@@]12[C@](CC[C@]2([H])[C@@H](CC(O)=O)C)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4([C@](C[C@@H](CC4)O)([H])C[C@@H]3O)C. InChi Code: InChI=1S/C23H38O4/c1-13(10-20(26)27)16-4-5-17-21-18(7-9-23(16,17)3)22(2)8-6-15(24)11-14(22)12-19(21)25/h13-19,21,24-25H,4-12H2,1-3H3,(H,26,27)/t13-,14+,15-,16-,17+,18+,19+,21+,22+,23-/m1/s1. InChi Key: QYYDXDSPYPOWRO-JHMCBHKWSA-N.