N-Lignoceroyl Taurine

Several different arachidonoyl amino acid conjugates, including N-arachidonoyl dopamine and N-arachidonoyl-L-serine, have been isolated and characterized from bovine brain. N-lignoceroyl taurine is one of several novel taurine-conjugated fatty acids discovered during mass spectrometry lipidomic analysis of brain and spinal cord from wild-type and fatty acid amide hydrolase (FAAH) knockout mice. The levels of N-lignoceroyl taurine were elevated 23-26 fold in FAAH-/- mice compared to wild-type mice, indicating that FAAH utilizes N-lignoceroyl taurine as a substrate. However, in vitro experiments with purified FAAH indicate N-lignoceroyl taurine is hydrolyzed 2,000 times more slowly by FAAH compared to oleoyl ethanolamide. N-acyl taurines bearing polyunsaturated acyl chains can activate members of the transient receptor potential (TRP) family of calcium channels, including TRPV1 and TRPV4.Formal Name: 2-[(1-oxotetracosyl)amino]-ethanesulfonic acid. CAS Number: 807370-75-8. Molecular Formula: C26H53NO4S. Formula Weight: 475.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2.5 mg/ml, DMSO: 5 mg/ml, Ethanol: 0.15 mg/ml, PBS (pH 7.2): 0.1 mg/ml. SMILES: CCCCCCCCCCCCCCCCCCCCCCCC(NCCS(=O)(O)=O)=O. InChi Code: InChI=1S/C26H53NO4S/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-26(28)27-24-25-32(29,30)31/h2-25H2,1H3,(H,27,28)(H,29,30,31). InChi Key: DDCFSFYOVZMRHL-UHFFFAOYSA-N.