MPLA

MPLA
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay25998-100 100 µg -

6 - 10 business days*

395.00€
 
MPLA is a synthetic derivative of lipid A, a component of bacterial LPS, that is hexa-acylated in... more
Product information "MPLA"
MPLA is a synthetic derivative of lipid A, a component of bacterial LPS, that is hexa-acylated in contrast to lipid A monophosphoryl from S. minnesota R595 (Cay-25848), which can be hepta-, hexa-, or penta-acylated. MPLA is an agonist of toll-like receptor 4 (TLR4). Intramuscular injection of MPLA (5 µg/100 µl) in mice increases injection site transcription of MyD88- and TRIF-dependent genes as well as genes encoding cytokines and cytokine receptors, chemokines, and molecules involved in the complement pathway and antigen presentation. It also increases the number of CD3+ T cells and CD11c+ GR1+ dendritic cells recruited to draining lymph nodes and increases serum levels of CCL2/MCP-1, CXCL1, CSF3, IL-6, and IL-10 by more than 10-fold compared to control animals. Emulsions containing MPLA have demonstrated efficacy as vaccine adjuvants in several mouse models, enhancing immune responses to HIV gp140 antigen and providing protection against M. tuberculosis infection.Formal Name: 3-[(3R)-3-hydroxytetradecanoate], 2-deoxy-6-O-[2-deoxy-3-O-[(3R)-1-oxo-3-[(1-oxotetradecyl)oxy]tetradecyl]-2-[[(3R)-1-oxo-3-[(1-oxotetradecyl)oxy]tetradecyl]amino]-4-O-phosphono-beta-D-glucopyranosyl]-2-[[(3R)-3-hydroxy-1-oxotetradecyl]amino]-alpha-D-glucopyranose, monoammonium salt. CAS Number: 1246298-63-4. Synonyms: Glucopyranosyl Lipid A, Monophosphoryl Lipid A. Molecular Formula: C96H180N2O22P . NH4. Formula Weight: 1763.5. Formulation: (Request formulation change), A solution in sterile, double distilled water. Solubility: DMSO: 1 mg/ml. SMILES: OC[C@H]1O[C@@H](OC[C@H]2O[C@H](O)[C@H](NC(C[C@H](O)CCCCCCCCCCC)=O)[C@@H](OC(C[C@H](O)CCCCCCCCCCC)=O)[C@@H]2O)[C@H](NC(C[C@H](OC(CCCCCCCCCCCCC)=O)CCCCCCCCCCC)=O)[C@@H](OC(C[C@H](OC(CCCCCCCCCCCCC)=O)CCCCCCCCCCC)=O)[C@@H]1OP([O-])(O)=O.[NH4+]. InChi Code: InChI=1S/C96H181N2O22P.H3N/c1-7-13-19-25-31-37-39-45-51-57-63-69-85(104)114-79(67-61-55-49-43-35-29-23-17-11-5)73-84(103)98-90-94(119-88(107)74-80(68-62-56-50-44-36-30-24-18-12-6)115-86(105)70-64-58-52-46-40-38-32-26-20-14-8-2)92(120-121(110,111)112)81(75-99)117-96(90)113-76-82-91(108)93(118-87(106)72-78(101)66-60-54-48-42-34-28-22-16-10-4)89(95(109)116-82)97-83(102)71-77(100)65-59-53-47-41-33-27-21-15-9-3./h77-82,89-96,99-101,108-109H,7-76H2,1-6H3,(H,97,102)(H,98,103)(H2,110,111,112).1H3/t77-,78-,79-,80-,81-,82-,89-,90-,91-,92-,93-,94-,95+,96-./m1./s1. InChi Key: UPAZUDUZKTYFBG-HNPUZVNISA-N.
Keywords: Glucopyranosyl Lipid A, Monophosphoryl Lipid A, 3-[(3R)-3-hydroxytetradecanoate], 2-deoxy-6-O-[2-deoxy-3-O-[(3R)-1-oxo-3-[(1-oxotetradecyl)oxy]tetradecyl]-2-[[(3R)-1-oxo-3-[(1-oxotetradecyl)oxy]tetradecyl]amino]-4-O-phosphono-beta-D-glucopyranosyl]-2-[[(3
Supplier: Cayman Chemical
Supplier-Nr: 25998

Properties

Application: Synthetic lipid A derivative, TLR4 agonist
MW: 1763.5 D
Formula: C96H180N2O22P . NH4
Format: Solution

Database Information

CAS : 1246298-63-4| Matching products
KEGG ID : K10160 | Matching products

Handling & Safety

Storage: +4°C
Shipping: +20°C (International: +4°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H335, H371, H373
P Phrases: P260, P261, P264, P270, P271, P304+340, P308+311, P312, P314, P403+233, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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