Cookie preferences
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Track device being used
![MPLA](https://www.biomol.com/media/image/2d/d5/c5/Cay25998-100_600x600.png)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay25998-100 | 100 µg | - |
6 - 10 business days* |
395.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
MPLA is a synthetic derivative of lipid A, a component of bacterial LPS, that is hexa-acylated in... more
Product information "MPLA"
MPLA is a synthetic derivative of lipid A, a component of bacterial LPS, that is hexa-acylated in contrast to lipid A monophosphoryl from S. minnesota R595 (Cay-25848), which can be hepta-, hexa-, or penta-acylated. MPLA is an agonist of toll-like receptor 4 (TLR4). Intramuscular injection of MPLA (5 µg/100 µl) in mice increases injection site transcription of MyD88- and TRIF-dependent genes as well as genes encoding cytokines and cytokine receptors, chemokines, and molecules involved in the complement pathway and antigen presentation. It also increases the number of CD3+ T cells and CD11c+ GR1+ dendritic cells recruited to draining lymph nodes and increases serum levels of CCL2/MCP-1, CXCL1, CSF3, IL-6, and IL-10 by more than 10-fold compared to control animals. Emulsions containing MPLA have demonstrated efficacy as vaccine adjuvants in several mouse models, enhancing immune responses to HIV gp140 antigen and providing protection against M. tuberculosis infection.Formal Name: 3-[(3R)-3-hydroxytetradecanoate], 2-deoxy-6-O-[2-deoxy-3-O-[(3R)-1-oxo-3-[(1-oxotetradecyl)oxy]tetradecyl]-2-[[(3R)-1-oxo-3-[(1-oxotetradecyl)oxy]tetradecyl]amino]-4-O-phosphono-beta-D-glucopyranosyl]-2-[[(3R)-3-hydroxy-1-oxotetradecyl]amino]-alpha-D-glucopyranose, monoammonium salt. CAS Number: 1246298-63-4. Synonyms: Glucopyranosyl Lipid A, Monophosphoryl Lipid A. Molecular Formula: C96H180N2O22P . NH4. Formula Weight: 1763.5. Formulation: (Request formulation change), A solution in sterile, double distilled water. Solubility: DMSO: 1 mg/ml. SMILES: OC[C@H]1O[C@@H](OC[C@H]2O[C@H](O)[C@H](NC(C[C@H](O)CCCCCCCCCCC)=O)[C@@H](OC(C[C@H](O)CCCCCCCCCCC)=O)[C@@H]2O)[C@H](NC(C[C@H](OC(CCCCCCCCCCCCC)=O)CCCCCCCCCCC)=O)[C@@H](OC(C[C@H](OC(CCCCCCCCCCCCC)=O)CCCCCCCCCCC)=O)[C@@H]1OP([O-])(O)=O.[NH4+]. InChi Code: InChI=1S/C96H181N2O22P.H3N/c1-7-13-19-25-31-37-39-45-51-57-63-69-85(104)114-79(67-61-55-49-43-35-29-23-17-11-5)73-84(103)98-90-94(119-88(107)74-80(68-62-56-50-44-36-30-24-18-12-6)115-86(105)70-64-58-52-46-40-38-32-26-20-14-8-2)92(120-121(110,111)112)81(75-99)117-96(90)113-76-82-91(108)93(118-87(106)72-78(101)66-60-54-48-42-34-28-22-16-10-4)89(95(109)116-82)97-83(102)71-77(100)65-59-53-47-41-33-27-21-15-9-3./h77-82,89-96,99-101,108-109H,7-76H2,1-6H3,(H,97,102)(H,98,103)(H2,110,111,112).1H3/t77-,78-,79-,80-,81-,82-,89-,90-,91-,92-,93-,94-,95+,96-./m1./s1. InChi Key: UPAZUDUZKTYFBG-HNPUZVNISA-N.
Keywords: | Glucopyranosyl Lipid A, Monophosphoryl Lipid A, 3-[(3R)-3-hydroxytetradecanoate], 2-deoxy-6-O-[2-deoxy-3-O-[(3R)-1-oxo-3-[(1-oxotetradecyl)oxy]tetradecyl]-2-[[(3R)-1-oxo-3-[(1-oxotetradecyl)oxy]tetradecyl]amino]-4-O-phosphono-beta-D-glucopyranosyl]-2-[[(3 |
Supplier: | Cayman Chemical |
Supplier-Nr: | 25998 |
Properties
Application: | Synthetic lipid A derivative, TLR4 agonist |
MW: | 1763.5 D |
Formula: | C96H180N2O22P . NH4 |
Format: | Solution |
Database Information
CAS : | 1246298-63-4| Matching products |
KEGG ID : | K10160 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +20°C (International: +4°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
![]() ![]() |
H Phrases: | H335, H371, H373 |
P Phrases: | P260, P261, P264, P270, P271, P304+340, P308+311, P312, P314, P403+233, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
more
You will get a certificate here
Viewed