Menaquinone 4

Menaquinone 4 (MK-4) is the predominant homolog of vitamin K2 and is composed of a naphthoquinone base with four isoprenoid units in the side chain. It is formed primarily via conversion of vitamin K1 (Cay-21051) in vivo and accumulates in various tissues, including the brain. MK-4 halts the cell cycle at the G phase in HepG2, Hep3B, and Huh7 hepatocellular carcinoma cells in a concentration-dependent manner. It also inhibits IkappaB kinase (IKK) activity, IkappaBalpha phosphorylation, and the transcriptional activity of NF-kappaB. Vitamin K2 may have a role in bone metabolism.Formal Name: 2-methyl-3-[(2E,6E,10E)-3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraen-1-yl]-1,4-naphthalenedione. CAS Number: 863-61-6. Synonyms: MK-4, Vitamin K2(20). Molecular Formula: C31H40O2. Formula Weight: 444.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Chloroform: 100 mg/ml. lambdamax: 248, 269, 329 nm. SMILES: O=C1C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/C)=C(C)C(C2=CC=CC=C21)=O. InChi Code: InChI=1S/C31H40O2/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-17-25(5)20-21-27-26(6)30(32)28-18-7-8-19-29(28)31(27)33/h7-8,12,14,16,18-20H,9-11,13,15,17,21H2,1-6H3/b23-14+,24-16+,25-20+. InChi Key: DKHGMERMDICWDU-GHDNBGIDSA-N.