Medroxyprogesterone 17-acetate

Medroxyprogesterone 17-acetate is a synthetic progestogen.,, It prevents fertilization and increases the rate of transport of eggs from the fallopian tubes to the uterus in female ferrets when administered prior to ovulation. Medroxyprogesterone 17-acetate reversibly blocks ovulation in rats when injected on the last day of diestrus. It also has anti-androgenic activity in rats, decreasing plasma testosterone (Cay-15645, Cay-ISO60154) levels via induction of hepatic testosterone reductase activity. Medroxyprogesterone 17-acetate exhibits immunosuppressive effects in vitro and in vivo, inhibiting the production of IFN-gamma by CD2/CD3/CD28-stimulated peripheral blood mononuclear cells (PBMCs) at concentrations >10 nM and extending the survival of rabbit skin allografts., Injectable formulations containing medroxyprogesterone 17-acetate have been used as contraceptives.Formal Name: 17-(acetyloxy)-6alpha-methyl-pregn-4-ene-3,20-dione. CAS Number: 71-58-9. Synonyms: NSC 21171, NSC 26386, U-8839. Molecular Formula: C24H34O4. Formula Weight: 386.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: Slightly Soluble, Methanol: Slightly Soluble. SMILES: C[C@@]12[C@](CC[C@]2(OC(C)=O)C(C)=O)([H])[C@]3([H])C[C@H](C)C4=CC(CC[C@]4(C)[C@@]3([H])CC1)=O. InChi Code: InChI=1S/C24H34O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h13-14,18-20H,6-12H2,1-5H3/t14-,18+,19-,20-,22+,23-,24-/m0/s1. InChi Key: PSGAAPLEWMOORI-PEINSRQWSA-N.