MAGL Inhibitor Compound 23

MAGL inhibitor compound 23 is an inhibitor of monoacylglycerol lipase (MAGL, IC50 = 80 nM). It is selective for MAGL over cannabinoid receptor 1 (CB1), CB2, fatty acid amide hydrolase (FAAH), alpha/beta-hydrolase domain-containing protein 6 (ABHD6), and ABHD12 (IC50s = >10 µM). MAGL inhibitor compound 23 inhibits the growth of HCT116, MDA-MB-231, Caov-3, OVCAR-3, and SKOV3 cells (IC50s = 21, 7.9, 25, 57, and 15 µM, respectively) but not MRC5 cells (IC50 = >100 µM). It increases the levels of 2-arachidonoyl glycerol (2-AG, Cay-62160) in mouse brain and plasma when administered at a dose of 50 mg/kg.Formal Name: (1-(2-fluoro-5-hydroxybenzoyl)piperidin-4-yl)(4-isopropylphenyl)methanone. CAS Number: 2324160-91-8. Molecular Formula: C22H24FNO3. Formula Weight: 369.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS (pH 7.2) (1:6): 0.14 mg/ml, DMSO: 20 mg/ml, Ethanol: 2.5 mg/ml. lambdamax: 254 nm. SMILES: CC(C)C1=CC=C(C(C2CCN(C(C3=CC(O)=CC=C3F)=O)CC2)=O)C=C1. InChi Code: InChI=1S/C22H24FNO3/c1-14(2)15-3-5-16(6-4-15)21(26)17-9-11-24(12-10-17)22(27)19-13-18(25)7-8-20(19)23/h3-8,13-14,17,25H,9-12H2,1-2H3. InChi Key: WUUBZNFATQKRPH-UHFFFAOYSA-N.