Loxoprofen (sodium salt)

Loxoprofen is a non-steroidal anti-inflammatory drug (NSAID) and prodrug form of loxoprofen-SRS. It inhibits COX-1 and COX-2 in isolated human whole blood (IC50s = 6.5 and 13.5 µM, respectively). Loxoprofen reduces acetic acid-induced writhing in mice and carrageenan-induced paw edema and LPS-induced fever in rats (ED30s = 20.1, 0.7, and 2.79 mg/kg, respectively). Formulations containing loxoprofen have been used in the treatment of pain associated with osteoarthritis, myalgia, and post-traumatic swelling.Formal Name: alpha-methyl-4-[(2-oxocyclopentyl)methyl]-benzeneacetic acid, monosodium salt. CAS Number: 80382-23-6. Molecular Formula: C15H18O3 . Na. Formula Weight: 269.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. lambdamax: 223 nm. SMILES: O=C(C(C)C1=CC=C(CC2C(CCC2)=O)C=C1)O.[Na]. InChi Code: InChI=1S/C15H18O3.Na/c1-10(15(17)18)12-7-5-11(6-8-12)9-13-3-2-4-14(13)16,/h5-8,10,13H,2-4,9H2,1H3,(H,17,18),. InChi Key: IEPGDDWZDRJSIT-UHFFFAOYSA-N.