Lipid OA2 (hydrochloride)

Lipid OA2 is an ionizable cationic lipid that has been used in the generation of single-component lipid nanoparticles (LNPs) for the delivery of siRNA. LNPs containing lipid OA2 and siRNA targeting the gene encoding suppressor of cytokine signaling 1 (Socs1) decrease Socs1 expression by approximately 50% in isolated mouse bone marrow dendritic cells (BMDCs). Vaccination with ovalbumin-induced isolated mouse BMDCs transfected with LNPs composed of lipid OA2 and Socs1-targeting siRNA increases survival and decreases tumor volume in a B16-OVA murine melanoma model.Formal Name: di((Z)-octadec-9-en-1-yl) L-lysyl-L-glutamate, dihydrochloride. Synonyms: KE-oleyl. Molecular Formula: C47H89N3O5 . 2HCl. Formula Weight: 849.1. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Methanol: Soluble. SMILES: NCCCC[C@@H](C(N[C@@H](CCC(OCCCCCCCC/C=C\CCCCCCCC)=O)C(OCCCCCCCC/C=C\CCCCCCCC)=O)=O)N.Cl.Cl. InChi Code: InChI=1S/C47H89N3O5.2ClH/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-35-41-54-45(51)39-38-44(50-46(52)43(49)37-33-34-40-48)47(53)55-42-36-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2,,/h17-20,43-44H,3-16,21-42,48-49H2,1-2H3,(H,50,52),2*1H/b19-17-,20-18-,,/t43-,44-,,/m0../s1. InChi Key: DBWZQQDZKDSHKF-CTLKWHTASA-N.