Ligustrazine (hydrochloride)

Ligustrazine is a compound that has been found in L. wallichii and has diverse biological activities, including antioxidant, anti-inflammatory, neuroprotective, and anticancer properties. It inhibits hydrogen peroxide-induced decreases in cell viability and the levels of superoxide dismutase (SOD) and glutathione peroxidase (GPX) and increases in reactive oxygen species (ROS) and malondialdehyde (MDA) levels in human umbilical vein endothelial cells (HUVECs) when used at concentrations of 100 and 150 µg/ml. Ligustrazine (50 and 100 µM) inhibits prostaglandin E2 (PGE2, Cay-14010) production induced by LPS and IFN-gamma in primary rat glia. It reduces infarct volume, cortical edema, and cortical PGE2 levels in a rat model of transient focal cerebral ischemia induced by common carotid artery and middle cerebral artery occlusion when administered at a dose of 20 mg/kg. Ligustrazine inhibits the proliferation of MG-63, Saos-2, and U2OS osteosarcoma cells (IC50s = 10.3, 24.7, and 54.7 mg/ml, respectively) in vitro and reduces tumor growth in an MG-63 mouse xenograft model when administered at a dose of 100 mg/kg every other day.Formal Name: 2,3,5,6-tetramethyl-pyrazine, hydrochloride. CAS Number: 76494-51-4. Synonyms: 2,3,5,6-Tetramethylpyrazine. Molecular Formula: C8H12N2 . XHCl. Formula Weight: 136.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 212, 293 nm. SMILES: CC1=C(C)N=C(C)C(C)=N1.Cl. InChi Code: InChI=1S/C8H12N2.ClH/c1-5-6(2)10-8(4)7(3)9-5,/h1-4H3,1H. InChi Key: RQKFOGXUTRDQPB-UHFFFAOYSA-N. Origin: Synthetic.