Ketorolac (calcium salt)

Ketorolac is a non-steroidal anti-inflammatory drug (NSAID) and a non-selective COX inhibitor (IC50 = 20 nM for both COX-1 and COX-2). It prevents increases in paw swelling, increases paw withdrawal latency in a hot-plate test, and decreases prostaglandin E2 (PGE2) levels in paw tissue in a mouse model of carrageenan-induced inflammation when administered at a dose of 30 mg/kg. Ketorolac is a racemic mixture containing the active (S)-ketorolac (Cay-11348) and inactive (R)-ketorolac enantiomers. Formulations containing ketorolac have been used to manage postoperative pain and as ophthalmic solutions to treat ocular pain and inflammation.Formal Name: 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid, hemicalcium salt. CAS Number: 167105-81-9. Molecular Formula: C15H12NO3 . 1/2Ca. Formula Weight: 274.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 1 mg/ml, DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml. lambdamax: 246, 315 nm. SMILES: O=C(C1=CC=C2N1CCC2C([O-])=O)C3=CC=CC=C3.O=C(C4=CC=C5N4CCC5C([O-])=O)C6=CC=CC=C6.[Ca+2]. InChi Code: InChI=1S/2C15H13NO3.Ca/c2*17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13,/h2*1-7,11H,8-9H2,(H,18,19),/q,,+2/p-2. InChi Key: NPCGTDZMTWNBDA-UHFFFAOYSA-L.