Isoscopoletin

Isoscopoletin is a coumarin that has been found in D. fragrans and has diverse biological activities and is an active metabolite of scoparone (Cay-20046). It is formed from scoparone by the cytochrome P450 (CYP) isoform Cyp2c29 in mouse liver microsomes. Isoscopoletin is cytotoxic to A549 lung, MCF-7 breast, and HepG2 liver cancer cells (IC50s = 5.25, 8.58, and 4.76 µM, respectively). It is active against Gram-positive and Gram-negative bacteria, including S. aureus and E. coli, respectively, in agar diffusion assays. Isoscopoletin inhibits 15-lipoxygenase (15-LO, IC50 = 15.1 µM) and reduces paw thickness in a rat model of carrageenan-induced paw edema when administered at a dose of 0.1 mg/kg.Formal Name: 6-hydroxy-7-methoxy-2H-1-benzopyran-2-one. CAS Number: 776-86-3. Synonyms: Esculetin 7-methyl ether, 7-methoxy-6-Hydroxycoumarin, 7-Methoxyesculetin. Molecular Formula: C10H8O4. Formula Weight: 192.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: 1 mg/ml. lambdamax: 231 nm. SMILES: O=C1OC2=C(C=C1)C=C(O)C(OC)=C2. InChi Code: InChI=1S/C10H8O4/c1-13-9-5-8-6(4-7(9)11)2-3-10(12)14-8/h2-5,11H,1H3. InChi Key: SYTYLPHCLSSCOJ-UHFFFAOYSA-N. Origin: Plant/Erigeron breviscapus.