Hydrocortisone-d4

Hydrocortisone-d4 is intended for use as an internal standard for the quantification of hydrocortisone/cortisol (Cay-20739) by GC- or LC-MS. Cortisol, known as hydrocortisone when used as a therapeutic, is a glucocorticoid produced by the adrenal cortex in response to adrenocorticotropic hormone (ACTH). It is an agonist at the mineralocorticoid receptor (MR) and the glucocorticoid receptor (GR), with an approximately 6- to 10-fold greater affinity for MR. Cortisol production is increased during periods of stress, and it is a major effector molecule in the hypothalamic-pituitary-adrenal axis (HPA) stress response. Cortisol levels increase with age and are often elevated in major depressive disorder, certain forms of hypertension, and Parkinson's disease.Formal Name: (11beta)-11,17,21-trihydroxy-pregn-4-ene-3,20-dione-9,11,12,12-d4. CAS Number: 73565-87-4. Synonyms: Cortisol-d4. Molecular Formula: C21H26D4O5. Formula Weight: 366.5. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml, DMSO: 20 mg/ml, Ethanol: 2 mg/ml. SMILES: O=C1CC[C@@]2(C)C(CC[C@]3([H])[C@]2([2H])[C@](O)([2H])C([2H])([2H])[C@@]4(C)[C@@]3([H])CC[C@]4(O)C(CO)=O)=C1. InChi Code: InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1/i10D2,16D,18D. InChi Key: JYGXADMDTFJGBT-BJJKTIQHSA-N. Origin: Synthetic.