H1L1A1B3

H1L1A1B3
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay41199-5 5 mg -

6 - 10 business days*

136.00€
Cay41199-10 10 mg -

6 - 10 business days*

243.00€
Cay41199-25 25 mg -

6 - 10 business days*

576.00€
Cay41199-50 50 mg -

6 - 10 business days*

1,017.00€
 
H1L1A1B3 is an ionizable cationic lipid that has been used in combination with other lipids in... more
Product information "H1L1A1B3"
H1L1A1B3 is an ionizable cationic lipid that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for the delivery of circular RNA (circRNA) in vitro and in vivo. LNPs containing H1L1A1B3 and encapsulating circRNA encoding IL-12 induce IL-12 production four times more effectively than LNPs containing ALC-0315 (Cay-34337) and encapsulating the same circRNA in LLC1 murine Lewis lung carcinoma cells. Administration of LNPs containing H1L1A1B3 and encapsulating circRNA encoding IL-12 reduces tumor growth in an LLC1 murine Lewis lung carcinoma model in combination with an antibody against programmed cell death ligand 1 (PD-L1).Formal Name: 7-(cyclohexylamino)-6-(N-(3-(dimethylamino)propyl)-4-methylnonanamido)-7-oxoheptyl dodecanoate. Molecular Formula: C40H77N3O4. Formula Weight: 664.1. Purity: >95%. Formulation: (Request formulation change), A solution in ethanol. Solubility: Ethanol: Soluble: >10 mg/ml. SMILES: O=C(C(CCCCCOC(CCCCCCCCCCC)=O)N(CCCN(C)C)C(CCC(C)CCCCC)=O)NC1CCCCC1. InChi Code: InChI=1S/C40H77N3O4/c1-6-8-10-11-12-13-14-15-22-29-39(45)47-34-23-17-21-28-37(40(46)41-36-26-19-16-20-27-36)43(33-24-32-42(4)5)38(44)31-30-35(3)25-18-9-7-2/h35-37H,6-34H2,1-5H3,(H,41,46). InChi Key: GIBXGBZJMJLFQW-UHFFFAOYSA-N.
Keywords: 7-(cyclohexylamino)-6-(N-(3-(dimethylamino)propyl)-4-methylnonanamido)-7-oxoheptyl dodecanoate
Supplier: Cayman Chemical
Supplier-Nr: 41199

Properties

Application: Ionizable cationic lipid, LNP formation
MW: 664.1 D
Formula: C40H77N3O4
Purity: >95%
Format: Solution

Database Information

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H225, H319, H333
P Phrases: P210, P233, P240, P241, P242, P243, P264, P280, P303+361+353, P304+312, P305+351+338, P337+313, P370+378, P403+235, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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