GSK1940029

GSK1940029 is a stearoyl-CoA desaturase (SCD) inhibitor. It increases palmitate-induced phosphorylation of p70 ribosomal S6 kinase 1 (p70S6K1) and lactate dehydrogenase (LDH) release from AML12 hepatocytes when used at a concentration of 20 µM. GSK1940029 (10 µM) also increases palmitate-induced increases in extracellular and intracellular triglyceride levels in AML12 hepatocytes, an effect that can be reversed by the mammalian target of rapamycin (mTOR) inhibitor torin 1 (Cay-10997).Formal Name: 1-[(3,4-dichlorophenyl)methyl]-N-[4-(hydroxymethyl)phenyl]-5-methyl-1H-1,2,3-triazole-4-carboxamide. CAS Number: 1150701-66-8. Molecular Formula: C18H16Cl2N4O2. Formula Weight: 391.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. lambdamax: 268 nm. SMILES: CC1=C(C(NC2=CC=C(CO)C=C2)=O)N=NN1CC3=CC(Cl)=C(Cl)C=C3. InChi Code: InChI=1S/C18H16Cl2N4O2/c1-11-17(18(26)21-14-5-2-12(10-25)3-6-14)22-23-24(11)9-13-4-7-15(19)16(20)8-13/h2-8,25H,9-10H2,1H3,(H,21,26). InChi Key: QQRGSFYTPBYCFD-UHFFFAOYSA-N.