Glycoursodeoxycholic Acid-d4

Glycoursodeoxycholic acid-d4 (GUDCA-d4) is intended for use as an internal standard for the quantification of GUDCA (Cay-21698) by GC- or LC-MS. GUDCA is a glycine-conjugated form of the secondary bile acid ursodeoxycholic acid (UDCA, Cay-15121). It has antioxidant effects in vitro in Barrett's esophagus cells and primary cultured rat neurons. GUDCA reduces the levels of inflammatory cytokines and prevents cell death induced by unconjugated bilirubin (Cay-17161) in an astroglial cell model of neonatal hyperbilirubinemia. Oral administration of GUDCA (500 mg/kg per day) decreases the severity of symptoms and increases the amount of A. muciniphila, a commensal bacterial species commonly decreased in patients with inflammatory bowel disease (IBD), in a mouse model of colitis.Formal Name: N-[(3alpha,5beta,7beta)-3,7-dihydroxy-24-oxocholan-24-yl-2,2,4,4-d4]-glycine. CAS Number: 2044276-17-5. Synonyms: GUDCA-d4, Ursodeoxycholyl Glycine-d4. Molecular Formula: C26H39D4NO5. Formula Weight: 453.7. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solid. Solubility: DMSO: slightly soluble, Methanol: slightly soluble. SMILES: C[C@H](CCC(NCC(O)=O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@@H](O)C[C@]4([H])C([2H])([2H])[C@H](O)C([2H])([2H])C[C@]4(C)[C@@]3([H])CC[C@@]21C. InChi Code: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/t15-,16+,17-,18-,19+,20+,21+,24+,25+,26-/m1/s1/i8D2,12D2. InChi Key: GHCZAUBVMUEKKP-ODDJOPSVSA-N.