Glycodeoxycholic Acid (hydrate)

Glycodeoxycholic acid (GDCA) is a glycine-conjugated form of the secondary bile acid deoxycholic acid (Cay-18231, Cay-20756). It induces a reversible, concentration-dependent reduction in myogenic tone in rats and decreases expression of the gene encoding the cytochrome P450 (CYP) isoform 7A1 (CYP7A1) in rabbits. Serum levels of GDCA are elevated in non-surviving patients with acetaminophen-induced acute liver failure (AALF) compared with survivors. GDCA levels are also increased in the plasma of patients with asthma.Formal Name: N-[(3alpha,5beta,12alpha)-3,12-dihydroxy-24-oxocholan-24-yl]-glycine, monohydrate. CAS Number: 1079043-81-4. Synonyms: GDCA. Molecular Formula: C26H43NO5 . H2O. Formula Weight: 467.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml, Ethanol: 1 mg/ml. SMILES: C[C@H](CCC(NCC(O)=O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])C[C@H](O)[C@@]21C.O. InChi Code: InChI=1S/C26H43NO5.H2O/c1-15(4-9-23(30)27-14-24(31)32)19-7-8-20-18-6-5-16-12-17(28)10-11-25(16,2)21(18)13-22(29)26(19,20)3,/h15-22,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32),1H2/t15-,16-,17-,18+,19-,20+,21+,22+,25+,26-,/m1./s1. InChi Key: DLOTUJUSJVIXDW-YEUHZSMFSA-N.