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Promotion:
Save 10% on all MaxSpec® products by Cayman Chemical!
*1
*1 Offer expires 30/09/2024
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Discount | Price |
---|---|---|---|---|---|---|---|---|
Cay31352-100 | 100 µg | - |
6 - 10 business days* |
10 %
|
205.00€
184.50€ |
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Glycocholic acid-d4 is intended for use as an internal standard for the quantification of... more
Product information "Glycocholic Acid-d4 MaxSpec(R) Standard"
Glycocholic acid-d4 is intended for use as an internal standard for the quantification of glycocholic acid (Cay-20276) by GC- or LC-MS. Glycocholic acid is a glycine-conjugated form of the primary bile acid cholic acid (Cay-20250) and has roles in the emulsification of fats. It reduces expression of the gene encoding the farnesoid X receptor (FXR) and increases expression of the genes encoding the bile acid receptors TGR5 and S1PR2 in SNU-245 cells when used at a concentration of 1.6 µmol/ml. Glycocholic acid (250 µM) increases the intracellular accumulation and cytotoxicity of epirubicin (Cay-12091) in Caco-2 cells, as well as decreases expression of the genes encoding multidrug resistance protein 1 (MDR1), MDR-associated protein 1 (MRP1), and MRP2 when used alone or in combination with epirubicin. It increases absorption of epirubicin into everted sacs of rat ileum and jejunum when used at a concentration of 250 µM. The bile acid composition ratio of glycocholic acid is elevated in bile of patients with cholangiocarcinoma compared with patients with pancreatic cancer or benign biliary diseases. Serum levels of glycocholic acid are elevated in patients with hepatocellular carcinoma compared with healthy individuals. Glycocholic acid-d4 MaxSpec(R) standard is a quantitative grade standard of glycocholic acid-d4 (Cay-21889) that has been prepared specifically for mass spectrometry and related applications where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This glycocholic acid-d4 MaxSpec(R) standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.Formal Name: N-[(3alpha,5beta,7alpha,12alpha)-3,7,12-trihydroxy-24-oxocholan-24-yl-2,2,4,4-d4]-glycine. CAS Number: 1201918-15-1. Synonyms: Cholylglycine-d4, GCA-d4. Molecular Formula: C26H39D4NO6. Formula Weight: 469.7. Purity: >95%. Formulation: (Request formulation change), A solution in methanol at 100 µg/ml. SMILES: C[C@H](CCC(NCC(O)=O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@H](O)C[C@]4([H])C([2H])([2H])[C@H](O)C([2H])([2H])C[C@]4(C)[C@@]3([H])C[C@H](O)[C@@]21C. InChi Code: InChI=1S/C26H43NO6/c1-14(4-7-22(31)27-13-23(32)33)17-5-6-18-24-19(12-21(30)26(17,18)3)25(2)9-8-16(28)10-15(25)11-20(24)29/h14-21,24,28-30H,4-13H2,1-3H3,(H,27,31)(H,32,33)/t14-,15+,16-,17-,18+,19+,20-,21+,24+,25+,26-/m1/s1/i8D2,10D2. InChi Key: RFDAIACWWDREDC-WZQUIQSLSA-N.
Keywords: | Cholylglycine-d4, GCA-d4, N-[(3alpha,5beta,7alpha,12alpha)-3,7,12-trihydroxy-24-oxocholan-24-yl-2,2,4,4-d4]-glycine |
Supplier: | Cayman Chemical |
Supplier-Nr: | 31352 |
Properties
Application: | Quantitative analytical standard, GC-MS, LC-MS, internal standard, secondary bile acid |
MW: | 469.7 D |
Formula: | C26H39D4NO6 |
Purity: | >95% |
Format: | Solution |
Database Information
CAS : | 1201918-15-1| Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Signal Word: | Danger |
GHS Hazard Pictograms: |
|
H Phrases: | H225, H301, H311, H331, H370 |
P Phrases: | P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P301+310, P302+352, P303+361+353, P304+340, P308+311, P311, P312, P321, P330, P361+364, P370+378, P403+233, P403+235, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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