GK187

GK187 is an inhibitor of Group VIA (GVIA) calcium-independent phospholipase A2 (iPLA2), an enzyme involved in basal cell metabolism. It inhibits GVIA iPLA2 by 99.8% at 0.091 mole fraction in a mixed micelle activity assay and is selective for GVIA iPLA2 over GIVA cPLA2 and GV sPLA2 where it shows less than 25% and 32.8% inhibition, respectively.Formal Name: 1,1,1,2,2-pentafluoro-7-(4-methoxyphenyl)-3-heptanone. CAS Number: 1071001-50-7. Molecular Formula: C14H15F5O2. Formula Weight: 310.3. Purity: >95%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 10 mg/ml, Ethanol:PBS (pH 7.2) (1:2): 0.3 mg/ml. lambdamax: 279 nm. SMILES: COC1=CC=C(CCCCC(C(F)(F)C(F)(F)F)=O)C=C1. InChi Code: InChI=1S/C14H15F5O2/c1-21-11-8-6-10(7-9-11)4-2-3-5-12(20)13(15,16)14(17,18)19/h6-9H,2-5H2,1H3. InChi Key: CICDFDPOGZQTQB-UHFFFAOYSA-N.