Gestodene-d6

Gestodene-d6 is intended for use as an internal standard for the quantification of gestodene (Cay-18217) by GC- or LC-MS. Gestodene is a progestin. It selectively binds to the progesterone receptor over the estrogen receptor. Gestodene induces transcriptional activity mediated by the progesterone receptor, and, weakly, the androgen receptor in reporter assays. It increases the growth of MCF-7 cells when used at concentrations ranging from 0.1 to 1 µM. In contrast, gestodene (0.1 mg/kg) reduces tumor growth in an estrogen-dependent model of rat mammary tumors induced by DMBA (Cay-30383). Formulations containing gestodene, in combination with ethynyl estradiol have been used as oral contraceptives.Formal Name: 13-ethyl-17alpha-hydroxy-18,19-dinorpregna-4,15-dien-20-yn-3-one-2,2,4,6,6,10-d6. CAS Number: 1542211-40-4. Molecular Formula: C21H20D6O2. Formula Weight: 316.5. Purity: >99% deuterated forms (d1-d6). Formulation: (Request formulation change), A solid. Solubility: Methanol: soluble. SMILES: CC[C@@]12[C@](C=C[C@@]2(O)C#C)([H])[C@@]3([H])[C@]([C@]4([2H])C(C([2H])([2H])C3)=C([2H])C(C([2H])([2H])C4)=O)([H])CC1. InChi Code: InChI=1S/C21H26O2/c1-3-20-11-9-17-16-8-6-15(22)13-14(16)5-7-18(17)19(20)10-12-21(20,23)4-2/h2,10,12-13,16-19,23H,3,5-9,11H2,1H3/t16-,17+,18+,19-,20-,21-/m0/s1/i5D2,6D2,13D,16D. InChi Key: SIGSPDASOTUPFS-PWFLSJGKSA-N.