Ganodermanondiol

Ganodermanondiol is a triterpenoid that has been found in G. lucidum and has diverse biological activities. It inhibits the proliferation of Meth A sarcoma and LLC1 lung carcinoma cells (IC50s = 3.4 and 12.5 µg/ml, respectively). Ganodermanondiol (20 µM) reduces the viability of RAW 264.7 macrophages. It inhibits superoxide generation in, and elastase release from, isolated human neutrophils induced by N-formyl-Met-Leu-Phe (fMLF, Cay-21495) and cytochalasin B (Cay-11328) with IC50 values of 6.36 and 5.01 µg/ml, respectively. Ganodermanondiol inhibits complement-dependent hemolysis of isolated sheep red blood cells (IC50 = 41.7 µM).Formal Name: 24S,25-dihydroxy-lanosta-7,9(11)-dien-3-one. CAS Number: 107900-76-5. Molecular Formula: C30H48O3. Formula Weight: 456.7. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. SMILES: C[C@]1(CC[C@]2([H])[C@H](C)CC[C@H](O)C(C)(O)C)C(C3=CC[C@@]12C)=CC[C@](C(C)4C)([H])[C@@]3(CCC4=O)C. InChi Code: InChI=1S/C30H48O3/c1-19(9-12-25(32)27(4,5)33)20-13-17-30(8)22-10-11-23-26(2,3)24(31)15-16-28(23,6)21(22)14-18-29(20,30)7/h10,14,19-20,23,25,32-33H,9,11-13,15-18H2,1-8H3/t19-,20-,23+,25+,28-,29-,30+/m1/s1. InChi Key: AAJIHHYEPHRIET-XEFAKFPISA-N. Origin: Fungus/Ganoderma sp..