Ganglioside GM2 Mixture (bovine brain) (ammonium salt)

Ganglioside GM2 is a glycosphingolipid component of cellular membranes, primarily the plasma membrane. Gangliosides isolated from apoptogenic glioblastoma multiforme (GBM) cells are enriched in ganglioside GM2 compared with nonapoptogenic GBM cells, and ganglioside GM2 induces activated T cell death when used at a concentration of 150 µg/ml in vitro. Serum ganglioside GM2 levels are increased in patients with breast cancer or cholangiocarcinoma. Levels of ganglioside GM2 are elevated in the brain of patients with Sandhoff disease, as well as feline and mouse models of the disease. Ganglioside GM2 accumulates in the lysosomes of individuals with Tay-Sachs disease and GM2-activator deficiency, as well as in the CNS of patients with and animal models of mucopolysaccharide storage disorders and Niemann-Pick disease types A, C1, and C2. Ganglioside GM2 mixture contains ganglioside GM2 molecular species isolated from bovine brain with primarily C18:0 fatty acyl chain lengths. As this product is derived from a natural source, there may also be variations in the sphingoid backbone. [Matreya, LLC. Catalog No. 1542]CAS Number: 19600-01-2. Synonyms: GM2 Mixture, Monosialoganglioside GM2 Mixture. Molecular Formula: C67H120N3O26 . NH4 (for stearoyl). Formula Weight: 1401.7. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Chloroform:Methanol:DI Water (2:1:0.1): soluble. SMILES: OC[C@H]1O[C@@H](O[C@H]2[C@H](O[C@H]([C@@H]([C@H]2O[C@]3(C([O-])=O)C[C@@H]([C@H]([C@]([C@@H]([C@H](O)CO)O)(O3)[H])NC(C)=O)O)O)O[C@H]4[C@@H]([C@H]([C@@H](O[C@@H]4CO)OC[C@@H]([C@H](O)/C=C/CCCCCCCCCCCCC)NC([R])=O)O)O)CO)[C@H](NC(C)=O)[C@@H](O)[C@H]1O.[NH4+]. InChi Code: InChI=1S/C67H121N3O26.H3N/c1-5-7-9-11-13-15-17-19-20-22-24-26-28-30-32-34-50(80)70-43(44(77)33-31-29-27-25-23-21-18-16-14-12-10-8-6-2)40-89-64-57(85)56(84)59(48(38-73)91-64)93-65-58(86)62(60(49(39-74)92-65)94-63-52(69-42(4)76)55(83)54(82)47(37-72)90-63)96-67(66(87)88)35-45(78)51(68-41(3)75)61(95-67)53(81)46(79)36-71,/h31,33,43-49,51-65,71-74,77-79,81-86H,5-30,32,34-40H2,1-4H3,(H,68,75)(H,69,76)(H,70,80)(H,87,88),1H3/b33-31+,/t43-,44+,45-,46+,47+,48+,49+,51+,52+,53+,54-,55+,56+,57+,58+,59+,60-,61+,62+,63-,64+,65-,67-,/m0./s1. InChi Key: OUYSNHGGXMUSJO-VUDKKWOPSA-N.