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Eupafolin is a flavonoid that has been found in E. adenophorum and has diverse biological activities. It inhibits iron-dependent lipid peroxidation in a cell-free assay (IC50 = 7.9 µM). Eupafolin (50-150 µM) inhibits prion protein 106-126 (PrP106-126) aggregation in a cell-free assay and reduces PrP106-126-induced cell death in SH-SY5Y cells. It inhibits the production of hemolysin and leukocidin by methicillin-susceptible S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA) and reduces S. aureus-induced hemolysis of erythrocytes in isolated rabbit whole blood when used at a concentration of 100 µM. In vivo, eupafolin (100 mg/kg) reduces the number of lung colony-forming units (CFUs) and increases survival in a mouse model of MRSA infection. It also reduces angiogenesis and tumor volume in a Hep3B hepatocellular carcinoma (HCC) mouse xenograft model when administered at a dose of 60 mg/kg.Formal Name: 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6-methoxy-4H-1-benzopyran-4-one. CAS Number: 520-11-6. Synonyms: 6-Methoxyluteolin, Nepetin. Molecular Formula: C16H12O7. Formula Weight: 316.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Methanol: Slightly soluble, Water: Slightly soluble. SMILES: O=C1C=C(C2=CC(O)=C(O)C=C2)OC3=CC(O)=C(C(O)=C13)OC. InChi Code: InChI=1S/C16H12O7/c1-22-16-11(20)6-13-14(15(16)21)10(19)5-12(23-13)7-2-3-8(17)9(18)4-7/h2-6,17-18,20-21H,1H3. InChi Key: FHHSEFRSDKWJKJ-UHFFFAOYSA-N. Origin: Plant/Salvia plebeia R. Br..
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