Etofenamate-d4

Etofenamate-d4 is intended for use as an internal standard for the quantification of etofenamate (Cay-23674) by GC- or LC-MS. Etofenamate is a non-steroidal anti-inflammatory drug (NSAID) and diethylene glycol ester form of flufenamic acid (Cay-21447) that has anti-inflammatory and analgesic activities. It inhibits lipoxygenase isolated from guinea pig leukocytes (IC50 = 5.3 µM) and the production of prostaglandin E2 (PGE2, Cay-14010) in stimulated rat peritoneal macrophages. In vivo, etofenamate reduces acetic acid-induced vascular permeability in mice and UV-induced erythema in guinea pigs in a dose-dependent manner at doses ranging from 40-320 and 5-20 mg/kg, respectively. Etofenamate (40 mg/kg per day for 21 days) inhibits inflammation in a rat model of adjuvant-induced arthritis. It also decreases the pain response in a silver nitrate-induced rat model of arthritis and the acetic acid-induced writhing test in mice, indicating analgesic activity. Formulations containing etofenamate have been used in the treatment of osteoarthritis.Formal Name: 2-(2-hydroxyethoxy)ethyl 2-((3-(trifluoromethyl)phenyl)amino)benzoate-3,4,5,6-d4. CAS Number: 1329837-73-1. Molecular Formula: C18H14D4F3NO4. Formula Weight: 373.4. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), An oil. Solubility: Acetonitrile: soluble, Methanol: soluble. SMILES: OCCOCCOC(C1=C(NC2=CC(C(F)(F)F)=CC=C2)C([2H])=C([2H])C([2H])=C1[2H])=O. InChi Code: InChI=1S/C18H18F3NO4/c19-18(20,21)13-4-3-5-14(12-13)22-16-7-2-1-6-15(16)17(24)26-11-10-25-9-8-23/h1-7,12,22-23H,8-11H2/i1D,2D,6D,7D. InChi Key: XILVEPYQJIOVNB-ZEJCXXMWSA-N.